The series also features a strong supporting cast, including Kelli Williams as Dr. Gillian Foster, whose husband is cheating on her, a fact everyone of her colleagues is aware of, except herself. Brendan Hines' character is always telling the truth no matter how embarrassing and Monica Raymund starrs as Ria Torres, who has the natural ability of seeing if someone is lying. That often leads to conflict with Lightman, who refuses to believe her ability is as accurate as his, since he needed years of training, while she was just born with her talent.
Yes, there are parallels with other series, especially "The Mentalist", but those are pretty much limited to the ability of the main character being able to detect the truth from people's movements and voices. Besides "Lie to Me" is focused on the science of detecting lies, something completely ignored in "The Mentalist". For example, it will take a person who's telling the truth longer to respond than one who's lying, because the one telling the truth needs to think about the answer.

For a small number of the early episodes Lightman would team up with Torres working on a case, while Foster and Loker would team up on a separate case. Occasionally their work would intertwine or Foster or Lightman would provide assistance on each others cases. As the first season progressed, the cases became more involved and all four of the main characters would work together on one case for each episode. This formulaic technique is often used in the first episodes of a new series to help establish the characters.
DR. CAL LIGHTMAN (Tim Roth) is the world's leading deception expert. If you lie to Lightman, he'll see it in your face and your posture or hear it in your voice. If you shrug your shoulder, rotate your hand or even just slightly raise your lower lip, Lightman will spot the lie. By analyzing facial expressions and involuntary body language, he can read feelings ranging from hidden resentment to sexual attraction to jealousy. His work gives him the knowledge and skill set to expertly deceive others as well as detect lies.

LIE TO ME is the compelling drama series inspired by the scientific discoveries of a real-life psychologist who can read clues embedded in the human face, body and voice to expose the truth and lies in criminal investigations.
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